DegronMD

Uniprot ID: Q8IZR5

Source protein: CKLF-like MARVEL transmembrane domain-containing protein 4

Source gene: CMTM4

Class: DEG_APCC_DBOX_1

Location: 36:44

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.738

ASA_SCORE: 81.1889

COIL: 0.7271

CONS_SCORE: 0.3728

DSS_SCORE: 0.412

HELIX: 0.0747

FCONS_SCORE: 0.6524

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I38T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	QRRGLAGLR	DEG_APCC_DBOX_1	0.7078
p.A39T	SW900	lung	COSMIC	QRRGLAGLR	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	DEG_APCC_DBOX_1	36:44	QRRGLAGLR	APC,CDC20,FZR1	0.738	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons