DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QRSYLPQIS
Uniprot ID:
Q9HB07
Source protein:
MYG1 exonuclease
Source gene:
MYG1
Class:
DEG_APCC_DBOX_1
Location:
368:376
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9924
ASA_SCORE:
106.4444
COIL:
0.8412
CONS_SCORE:
0.2936
DSS_SCORE:
0.632
HELIX:
0.1374
FCONS_SCORE:
0.4906
RIG_SCORE:
0.7697
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y371H
SIDM00704
Small Cell Lung Carcinoma
GDSC
QRSYLPQIS
DEG_APCC_DBOX_1
0.6118
Drug responses associated with MYG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRSYLPQIS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HB07
MYG1 exonuclease
DEG_APCC_DBOX_1
368:376
QRSYLPQIS
APC,CDC20,FZR1
0.9924
More...