DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QRVHLAPIP
Uniprot ID:
Q9UPZ9
Source protein:
Serine/threonine-protein kinase ICK
Source gene:
CILK1
Class:
DEG_APCC_DBOX_1
Location:
569:577
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9926
ASA_SCORE:
78.9333
COIL:
0.6956
CONS_SCORE:
0.3386
DSS_SCORE:
0.499
HELIX:
0.0787
FCONS_SCORE:
1.0111
RIG_SCORE:
0.7241
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CILK1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRVHLAPIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPZ9
Serine/threonine-protein kinase ICK
DEG_APCC_DBOX_1
569:577
QRVHLAPIP
APC,CDC20,FZR1
0.9926
More...