DegronMD

Uniprot ID: P46937

Source protein: Transcriptional coactivator YAP1

Source gene: YAP1

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8752

ASA_SCORE: 80.0111

COIL: 0.483

CONS_SCORE: 0.7113

DSS_SCORE: 0.4489

HELIX: 0.0391

FCONS_SCORE: 1.0394

RIG_SCORE: 0.7784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S184F	TCGA-14-1451	GBM	TCGA	QRYFLNHID	DEG_APCC_DBOX_1	0.2778
p.S184F	DO13384	GBM	ICGC	QRYFLNHID	DEG_APCC_DBOX_1	0.2778
p.T196I	TCGA-J7-A8I2	KIRP	TCGA	QRYFLNHID	DEG_APCC_DBOX_1	0.2778
p.T196I	DO223958	KIRP	ICGC	QRYFLNHID	DEG_APCC_DBOX_1	0.2778
p.S183F	SIDM00169	Head and Neck Carcinoma	GDSC	QRYFLNHID	DEG_APCC_DBOX_1	0.25
p.E178D	ACH-000585	Lung Cancer	CCLE	QRYFLNHID	DEG_APCC_DBOX_1	0.1111
p.E178D	EPLC-272H	lung	COSMIC	QRYFLNHID	DEG_APCC_DBOX_1	0.1111
p.M199I	ACH-000781	Lung Cancer	CCLE	QRYFLNHID	DEG_APCC_DBOX_1	0.1944
p.M199I	NCI-H2023	lung	COSMIC	QRYFLNHID	DEG_APCC_DBOX_1	0.1944
p.Q179P	ACH-000827	Skin Cancer	CCLE	QRYFLNHID	DEG_APCC_DBOX_1	0.1389
p.Q179P	WM793B	skin	COSMIC	QRYFLNHID	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46937	Transcriptional coactivator YAP1	DEG_APCC_DBOX_1	186:194	QRYFLNHID	APC,CDC20,FZR1	0.8752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons