DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
RAINNQYS
Uniprot ID:
Q9NRF2
Source protein:
SH2B adapter protein 1
Source gene:
SH2B1
Class:
CBL_APS
Location:
747:754
E3 ligase:
CBL
DEGRON score:
0.9944
ASA_SCORE:
70.2125
COIL:
0.513
CONS_SCORE:
0.7596
DSS_SCORE:
0.7752
HELIX:
0.0726
FCONS_SCORE:
1.6559
RIG_SCORE:
0.732
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A748V
TCGA-CK-4951
COAD
TCGA
RAINNQYS
CBL_APS
0.6936
p.A748V
DO10582
COAD
ICGC
RAINNQYS
CBL_APS
0.6936
p.H745Y
DO222837
MELA
ICGC
RAINNQYS
CBL_APS
0.2778
Drug responses associated with SH2B1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RAINNQYS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NRF2
SH2B adapter protein 1
CBL_APS
747:754
RAINNQYS
CBL
0.9944
More...
