DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
RAINNQYS
Uniprot ID:
Q9NRF2
Source protein:
SH2B adapter protein 1
Source gene:
SH2B1
Class:
CBL_APS
Location:
747:754
E3 ligase:
CBL
DEGRON score:
0.9944
ASA_SCORE:
70.2125
COIL:
0.513
CONS_SCORE:
0.7596
DSS_SCORE:
0.7752
HELIX:
0.0726
FCONS_SCORE:
1.6559
RIG_SCORE:
0.732
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A748V
TCGA-CK-4951
COAD
TCGA
RAINNQYS
CBL_APS
0.6936
p.A748V
DO10582
COAD
ICGC
RAINNQYS
CBL_APS
0.6936
p.H745Y
DO222837
MELA
ICGC
RAINNQYS
CBL_APS
0.2778
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Drug responses associated with SH2B1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of RAINNQYS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NRF2
SH2B adapter protein 1
CBL_APS
747:754
RAINNQYS
CBL
0.9944
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