DegronMD

Uniprot ID: P68400

Source protein: Casein kinase II subunit alpha

Source gene: CSNK2A1

Class: LIG_APCC_ABBAyCdc20_2

Location: 8:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9923

ASA_SCORE: 86.2143

COIL: 0.6107

CONS_SCORE: 0.6733

DSS_SCORE: 0.4801

HELIX: 0.2676

FCONS_SCORE: 1.2498

RIG_SCORE: 0.7515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E22Q	TCGA-85-A4CL	LUSC	TCGA	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E22Q	DO45454	LUSC	ICGC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A9D	TCGA-HU-A4GU	STAD	TCGA	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.6682
p.A9D	DO47849	STAD	ICGC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.6682
p.H18Q	DO228974	LICA	ICGC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D9E	DO41199	UCEC	ICGC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.6758
p.T13I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T13I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T13I	ACH-000995	Leukemia	CCLE	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T13I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.7078
p.R21G	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R21G	ACH-000496	Lung Cancer	CCLE	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R21G	NCI-H1792	lung	COSMIC	RARVYTD	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P68400	Casein kinase II subunit alpha	LIG_APCC_ABBAyCdc20_2	8:14	RARVYTD	APC,CDC20,FZR1	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons