DegronMD

Uniprot ID: Q92876

Source protein: Kallikrein-6

Source gene: KLK6

Class: LIG_APCC_ABBAyCdc20_2

Location: 91:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6375

ASA_SCORE: 54.8429

COIL: 0.437

CONS_SCORE: 0.5434

DSS_SCORE: 0.434

HELIX: 0.0181

FCONS_SCORE: 1.1348

RIG_SCORE: 0.7488

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D99N	TCGA-86-7954	LUAD	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D99N	DO23660	LUAD	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R91W	TCGA-FR-A726	SKCM	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R91W	DO48665	SKCM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.8634
p.V89L	TCGA-G2-A3VY	BLCA	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V89L	DO590	BLCA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A100V	DO227987	COCA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.T101M	DO10955	GBM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S102R	DO228971	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D97E	DO229029	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.5647
p.A101D	DO229042	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D106E	DO229008	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R106Q	DO220886	MELA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R106Q	DO37823	SKCM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R106Q	DO47362	SKCM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R94K	DO41488	UCEC	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.7237
p.H103N	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H103N	ACH-000414	Lung Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H103N	NCI-H1944	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q105H	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q105H	ACH-000481	Lung Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q105H	NCI-H2170	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A100T	SIDM00820	Kidney Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A100T	ACH-002188	Kidney Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A100T	RCC-ER	kidney	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.H99P	NCI-H446	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S90P	ASH-3	thyroid	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RAVIHPD

Degron related mutations and impact score

Drug responses associated with KLK6 mutations

All proteins holding degron of RAVIHPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92876	Kallikrein-6	LIG_APCC_ABBAyCdc20_2	91:97	RAVIHPD	APC,CDC20,FZR1	0.6375	More...