DegronMD

Uniprot ID: Q92876

Source protein: Kallikrein-6

Source gene: KLK6

Class: LIG_APCC_ABBAyCdc20_2

Location: 91:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6375

ASA_SCORE: 54.8429

COIL: 0.437

CONS_SCORE: 0.5434

DSS_SCORE: 0.434

HELIX: 0.0181

FCONS_SCORE: 1.1348

RIG_SCORE: 0.7488

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91W	TCGA-FR-A726	SKCM	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R91W	DO48665	SKCM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R94K	DO41488	UCEC	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.7237
p.D97E	DO229029	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.5647
p.S90P	ASH-3	thyroid	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D99N	TCGA-86-7954	LUAD	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D99N	DO23660	LUAD	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V89L	TCGA-G2-A3VY	BLCA	TCGA	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V89L	DO590	BLCA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H99P	NCI-H446	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A100V	DO227987	COCA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A100T	SIDM00820	Kidney Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A100T	ACH-002188	Kidney Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.A100T	RCC-ER	kidney	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.T101M	DO10955	GBM	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A101D	DO229042	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S102R	DO228971	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.H103N	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H103N	ACH-000414	Lung Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H103N	NCI-H1944	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q105H	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q105H	ACH-000481	Lung Cancer	CCLE	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q105H	NCI-H2170	lung	COSMIC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D106E	DO229008	LICA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R106Q	DO220886	MELA	ICGC	RAVIHPD	LIG_APCC_ABBAyCdc20_2	0.0833

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Drug responses associated with KLK6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RAVIHPD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92876	Kallikrein-6	LIG_APCC_ABBAyCdc20_2	91:97	RAVIHPD	APC,CDC20,FZR1	0.6375	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RAVIHPD

Degron related mutations and impact score

Drug responses associated with KLK6 mutations

All proteins holding degron of RAVIHPD