DegronMD

Uniprot ID: O43172

Source protein: U4/U6 small nuclear ribonucleoprotein Prp4

Source gene: PRPF4

Class: LIG_APCC_ABBAyCdc20_2

Location: 398:404

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5293

ASA_SCORE: 55.9

COIL: 0.1731

CONS_SCORE: 0.5965

DSS_SCORE: 0.0364

HELIX: 0.0056

FCONS_SCORE: 0.908

RIG_SCORE: 0.9457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R395L	TCGA-BR-4184	STAD	TCGA	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.25
p.G397E	TCGA-BR-A4PE	STAD	TCGA	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y410C	DO231954	LICA	ICGC	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D392Y	DO229009	LICA	ICGC	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G396E	DO47773	STAD	ICGC	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R394L	DO38328	STAD	ICGC	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.F414L	DO52412	UCEC	ICGC	RCIMFLE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43172	U4/U6 small nuclear ribonucleoprotein Prp4	LIG_APCC_ABBAyCdc20_2	398:404	RCIMFLE	APC,CDC20,FZR1	0.5293	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons