DegronMD

Uniprot ID: Q13426

Source protein: DNA repair protein XRCC4

Source gene: XRCC4

Class: LIG_APCC_ABBAyCdc20_2

Location: 225:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.99

ASA_SCORE: 111.2714

COIL: 0.8604

CONS_SCORE: 0.5743

DSS_SCORE: 0.7137

HELIX: 0.118

FCONS_SCORE: 1.0215

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R225Q	TCGA-4Z-AA87	BLCA	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R225Q	DO218990	BLCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.7329
p.E235D	TCGA-BF-A1PU	SKCM	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E235D	DO50278	SKCM	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E220Q	TCGA-BH-A0W7	BRCA	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E220Q	DO1272	BRCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D230N	TCGA-E9-A1NA	BRCA	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D230N	DO1522	BRCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D230N	DO222682	BTCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D230N	SIDM01776	Plasma Cell Myeloma	GDSC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D230N	ACH-001162	Myeloma	CCLE	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.R225L	TCGA-EE-A183	SKCM	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R225L	DO37715	SKCM	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.8428
p.E231K	TCGA-GC-A4ZW	BLCA	TCGA	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E231K	DO219024	BLCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.7022
p.M221I	DO225349	BRCA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D224Y	DO229024	LICA	ICGC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.T215I	SIDM02021	Esophageal Carcinoma	GDSC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S219F	SIDM00923	Cervical Carcinoma	GDSC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S219F	ACH-001336	Cervical Cancer	CCLE	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S219F	Ca-Ski	cervix	COSMIC	RDPVYDE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13426	DNA repair protein XRCC4	LIG_APCC_ABBAyCdc20_2	225:231	RDPVYDE	APC,CDC20,FZR1	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons