DegronMD

Uniprot ID: P51449

Source protein: Nuclear receptor ROR-gamma

Source gene: RORC

Class: LIG_APCC_ABBAyCdc20_2

Location: 111:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7665

ASA_SCORE: 96.7143

COIL: 0.2754

CONS_SCORE: 0.5526

DSS_SCORE: 0.623

HELIX: 0.7183

FCONS_SCORE: 0.9951

RIG_SCORE: 0.7091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R105C	TCGA-3N-A9WC	SKCM	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R105C	TCGA-EA-A410	CESC	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q119H	TCGA-AJ-A2QM	UCEC	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R125Q	TCGA-AX-A2HA	UCEC	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G104S	TCGA-F4-6570	COAD	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q124H	TCGA-FP-8211	STAD	TCGA	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G122R	DO223732	CESC	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G119V	DO20932	KIRP	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G119V	DO229264	THCA	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T125N	DO229022	LICA	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G122E	DO47305	SKCM	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q103H	DO47847	STAD	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R104Q	DO42504	UCEC	ICGC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P117T	MPP-89	pleura	COSMIC	RDSLHAE	LIG_APCC_ABBAyCdc20_2	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51449	Nuclear receptor ROR-gamma	LIG_APCC_ABBAyCdc20_2	111:117	RDSLHAE	APC,CDC20,FZR1	0.7665	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons