DegronMD

Uniprot ID: P35398

Source protein: Nuclear receptor ROR-alpha

Source gene: RORA

Class: LIG_APCC_ABBAyCdc20_2

Location: 153:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8425

ASA_SCORE: 94.6429

COIL: 0.3469

CONS_SCORE: 0.6878

DSS_SCORE: 0.619

HELIX: 0.6379

FCONS_SCORE: 1.0349

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V169I	TCGA-55-A492	LUAD	TCGA	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V169I	DO23708	LUAD	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V169I	SIDM00602	Gastric Carcinoma	GDSC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V169I	IM-95	stomach	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L163F	TCGA-A3-3313	KIRC	TCGA	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R152Q	TCGA-D7-6526	STAD	TCGA	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R152Q	DO38803	STAD	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N147K	TCGA-EO-A22U	UCEC	TCGA	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N147K	DO43755	UCEC	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N156S	TCGA-NH-A5IV	COAD	TCGA	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.7069
p.N156S	DO49095	COAD	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.7069
p.H160N	DO229026	LICA	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R157H	DO218866	SKCA	ICGC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R157H	SIDM00789	Colorectal Carcinoma	GDSC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R157H	HCT-15	large_intestine	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.N147S	SIDM00943	Pancreatic Carcinoma	GDSC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N147S	Capan-2	pancreas	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A167V	HCT-116	large_intestine	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S161F	MCC13	skin	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R149H	HCT-15	large_intestine	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V161I	IM-95	stomach	COSMIC	RDSLYAE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35398	Nuclear receptor ROR-alpha	LIG_APCC_ABBAyCdc20_2	153:159	RDSLYAE	APC,CDC20,FZR1	0.8425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons