DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RFLIFFD
Uniprot ID:
Q15047
Source protein:
Histone-lysine N-methyltransferase SETDB1
Source gene:
SETDB1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
292:298
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5946
ASA_SCORE:
17.9857
COIL:
0.0834
CONS_SCORE:
0.729
DSS_SCORE:
0.0327
HELIX:
0.0041
FCONS_SCORE:
1.3082
RIG_SCORE:
0.9891
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P285Q
TCGA-09-2044
OV
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.1389
p.P285Q
DO28923
OV
ICGC
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.1389
p.Q307L
TCGA-86-6562
LUAD
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.0833
p.Q307L
DO24013
LUAD
ICGC
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.0833
p.D298Y
TCGA-A1-A0SO
BRCA
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.7325
p.D299Y
TCGA-D6-A4ZB
HNSC
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.3056
p.D299Y
DO44446
HNSC
ICGC
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.3056
p.L294I
TCGA-EO-A22U
UCEC
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.6063
p.Y304C
TCGA-R8-A6MO
LGG
TCGA
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.1667
p.Y304C
DO48508
LGG
ICGC
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.1667
p.V305F
DO228985
LICA
ICGC
RFLIFFD
LIG_APCC_ABBAyCdc20_2
0.1389
Drug responses associated with SETDB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RFLIFFD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15047
Histone-lysine N-methyltransferase SETDB1
LIG_APCC_ABBAyCdc20_2
292:298
RFLIFFD
APC,CDC20,FZR1
0.5946
More...