DegronMD

Uniprot ID: Q15784

Source protein: Neurogenic differentiation factor 2

Source gene: NEUROD2

Class: LIG_APCC_ABBAyCdc20_2

Location: 350:356

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7332

ASA_SCORE: 73.6286

COIL: 0.7141

CONS_SCORE: 0.3818

DSS_SCORE: 0.2556

HELIX: 0.1481

FCONS_SCORE: 1.1655

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S346L	TCGA-93-8067	LUAD	TCGA	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S346L	DO25113	LUAD	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E356D	TCGA-CA-6717	COAD	TCGA	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E356D	DO8264	COAD	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.G351W	TCGA-D3-A2JN	SKCM	TCGA	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6714
p.G351W	DO47590	SKCM	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6714
p.R350H	TCGA-HU-8602	STAD	TCGA	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R350H	DO222765	COCA	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R350H	DO47829	STAD	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.G351R	DO233281	GACA	ICGC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6457
p.G345S	SIDM00333	Endometrial Carcinoma	GDSC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G345S	ACH-000988	Endometrial/Uterine Cancer	CCLE	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G345S	MFE-319	endometrium	COSMIC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G351V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6421
p.G351V	ACH-000945	Lung Cancer	CCLE	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6421
p.G351V	NCI-H650	lung	COSMIC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.6421
p.H364L	SIDM00497	Colorectal Carcinoma	GDSC	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H364L	ACH-000683	Colon/Colorectal Cancer	CCLE	RGGVHSE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15784	Neurogenic differentiation factor 2	LIG_APCC_ABBAyCdc20_2	350:356	RGGVHSE	APC,CDC20,FZR1	0.7332	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons