DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
RGKVFQD
Uniprot ID:
C9JC47
Source protein:
Putative protein FAM157A
Source gene:
FAM157A
Class:
LIG_APCC_ABBAyCdc20_2
Location:
294:300
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5981
ASA_SCORE:
71.8857
COIL:
0.6093
CONS_SCORE:
1
DSS_SCORE:
0.4693
HELIX:
0.0597
FCONS_SCORE:
1
RIG_SCORE:
0.75
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM157A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RGKVFQD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9JC47
Putative protein FAM157A
LIG_APCC_ABBAyCdc20_2
294:300
RGKVFQD
APC,CDC20,FZR1
0.5981
More...
P0CG43
Putative protein FAM157C
LIG_APCC_ABBAyCdc20_2
298:304
RGKVFQD
APC,CDC20,FZR1
0.5981
More...