DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RKAIHSD
Uniprot ID:
O60303
Source protein:
Katanin-interacting protein
Source gene:
KATNIP
Class:
LIG_APCC_ABBAyCdc20_2
Location:
85:91
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.995
ASA_SCORE:
106.8
COIL:
0.9119
CONS_SCORE:
0.3396
DSS_SCORE:
0.5368
HELIX:
0.058
FCONS_SCORE:
0.9871
RIG_SCORE:
0.6762
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R85Q
SIDM00216
Colorectal Carcinoma
GDSC
RKAIHSD
LIG_APCC_ABBAyCdc20_2
0.7329
p.R85Q
SIDM00283
B-Cell Non-Hodgkin's Lymphoma
GDSC
RKAIHSD
LIG_APCC_ABBAyCdc20_2
0.7329
Drug responses associated with KATNIP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKAIHSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60303
Katanin-interacting protein
LIG_APCC_ABBAyCdc20_2
85:91
RKAIHSD
APC,CDC20,FZR1
0.995
More...