DegronMD

Uniprot ID: Q9Y2L8

Source protein: Zinc finger protein with KRAB and SCAN domains 5

Source gene: ZKSCAN5

Class: DEG_APCC_KENBOX_2

Location: 247:251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8891

ASA_SCORE: 94.68

COIL: 0.6858

CONS_SCORE: 0.4743

DSS_SCORE: 0.3894

HELIX: 0.1466

FCONS_SCORE: 1.1685

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R247M	DO229037	LICA	ICGC	RKENY	DEG_APCC_KENBOX_2	0.7521
p.N250I	SIDM00143	Small Cell Lung Carcinoma	GDSC	RKENY	DEG_APCC_KENBOX_2	0.728
p.N250I	ACH-000803	Lung Cancer	CCLE	RKENY	DEG_APCC_KENBOX_2	0.728
p.N250I	COLO-668	lung	COSMIC	RKENY	DEG_APCC_KENBOX_2	0.728
p.Y243F	SIDM00502	B-Lymphoblastic Leukemia	GDSC	RKENY	DEG_APCC_KENBOX_2	0.2222
p.Y243F	ACH-000157	Lymphoma	CCLE	RKENY	DEG_APCC_KENBOX_2	0.2222
p.Y243F	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	RKENY	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2L8	Zinc finger protein with KRAB and SCAN domains 5	DEG_APCC_KENBOX_2	247:251	RKENY	APC,CDC20,FZR1	0.8891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons