DegronMD

Uniprot ID: P53350

Source protein: Serine/threonine-protein kinase PLK1

Source gene: PLK1

Class: LIG_APCC_ABBAyCdc20_2

Location: 441:447

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7467

ASA_SCORE: 48.9143

COIL: 0.387

CONS_SCORE: 0.3823

DSS_SCORE: 0.1086

HELIX: 0.0094

FCONS_SCORE: 0.8072

RIG_SCORE: 0.8912

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R441C	TCGA-AX-A1C9	UCEC	TCGA	RLILYND	LIG_APCC_ABBAyCdc20_2	0.8301
p.R441C	DO43098	UCEC	ICGC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.8301
p.R441C	SIDM00217	Colorectal Carcinoma	GDSC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.8301
p.R441C	ACH-000999	Colon/Colorectal Cancer	CCLE	RLILYND	LIG_APCC_ABBAyCdc20_2	0.8301
p.R441C	SNU-1040	large_intestine	COSMIC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.8301
p.R456C	TCGA-DK-A6AW	BLCA	TCGA	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.R456C	DO48566	BLCA	ICGC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.R456C	DO229211	THCA	ICGC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.D457G	TCGA-NH-A5IV	COAD	TCGA	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0556
p.D457G	DO49095	COAD	ICGC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0556
p.R456H	TCGA-XK-AAIW	PRAD	TCGA	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.R456H	DO51407	PRAD	ICGC	RLILYND	LIG_APCC_ABBAyCdc20_2	0.0833

Drug responses associated with PLK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (No)	GDSC	BI-2536	0.1445
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (No)	GDSC	GW843682X	0.1045
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (No)	GDSC	PLK_6522	0.4695
SIDM01164	LGG\|glioma	p.A520T (No)	GDSC	MK-1775	1.1087
SIDM00826	COREAD\|large_intestine	p.K601N (No)	GDSC	PLK_6522	0.6758
SIDM00826	COREAD\|large_intestine	p.K601N (No)	GDSC	MK-1775	1.3839
SIDM00797	SKCM\|melanoma	p.P355S (No)	GDSC	MK-1775	1.0078
SIDM00980	STAD\|stomach	p.Q242P (No)	GDSC	PLK_6522	0.0359
SIDM00980	STAD\|stomach	p.Q242P (No)	GDSC	MK-1775	0.8649
SIDM00214	COREAD\|large_intestine	p.R354H (No)	GDSC	PLK_6522	0.0315
SIDM00214	COREAD\|large_intestine	p.R354H (No)	GDSC	MK-1775	1.4325
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	BI-2536	0.3011
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	GW843682X	0.1448
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	PLK_6522	1.6712
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	MK-1775	27.949
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	BI-2536	0.0173
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	GW843682X	0.0082
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	PLK_6522	0.0078
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	MK-1775	0.3416
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R354H (No)	GDSC	PLK_6522	0.0682
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R354H (No)	GDSC	MK-1775	7.7584
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	BI-2536	0.0222
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	GW843682X	0.0165
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	PLK_6522	0.0325
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	MK-1775	1.3274
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	BI-2536	0.2057
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	GW843682X	0.0729
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	PLK_6522	0.0945
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	MK-1775	5.4403
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	BI-2536	0.028
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	GW843682X	0.0159
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	PLK_6522	0.0414
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	MK-1775	0.3487
SIDM00217	COREAD\|large_intestine	p.R441C (Yes)	GDSC	PLK_6522	1.7973
SIDM00217	COREAD\|large_intestine	p.R441C (Yes)	GDSC	MK-1775	1.0304
SIDM00140	SKCM\|melanoma	p.K265* (No)	GDSC	PLK_6522	0.1346
SIDM00140	SKCM\|melanoma	p.K265* (No)	GDSC	MK-1775	8.9573
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	BI-2536	0.0928
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	GW843682X	0.0444
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	PLK_6522	0.0142
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	MK-1775	0.3342
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.W410R (No)	GDSC	PLK_6522	0.026
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.W410R (No)	GDSC	MK-1775	0.3277
SIDM01096	COREAD\|large_intestine	p.Q283* (No)	GDSC	PLK_6522	0.0423
SIDM01096	COREAD\|large_intestine	p.Q283* (No)	GDSC	MK-1775	0.6997
SIDM00596	UCEC\|endometrium	p.R169* (No)	GDSC	PLK_6522	0.2797
SIDM00596	UCEC\|endometrium	p.R169* (No)	GDSC	MK-1775	2.7894
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	BI-2536	0.0143
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	GW843682X	0.0109
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	PLK_6522	0.3194
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	MK-1775	0.413
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	BI-2536	0.0177
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	GW843682X	0.0063
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	PLK_6522	0.2393
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	MK-1775	0.6095
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	BI-2536	0.0177
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	GW843682X	0.0063
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	PLK_6522	0.2393
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	MK-1775	0.6095
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.S595L (No)	GDSC	PLK_6522	0.032
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.S595L (No)	GDSC	MK-1775	3.1719
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	BI-2536	0.0905
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	GW843682X	0.0503
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	PLK_6522	0.0282
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	MK-1775	0.8099
SIDM00487	COREAD\|large_intestine	p.V587delV (No)	GDSC	PLK_6522	0.1707
SIDM00487	COREAD\|large_intestine	p.V587delV (No)	GDSC	MK-1775	0.4067
SIDM00379	GBM\|glioma	p.L261fs*60 (No)	GDSC	PLK_6522	0.0231
SIDM00379	GBM\|glioma	p.L261fs*60 (No)	GDSC	MK-1775	2.1473
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	BI-2536	0.2848
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	GW843682X	0.266
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	PLK_6522	0.0677
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.R364Q (No)	GDSC	PLK_6522	0.094
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.R364Q (No)	GDSC	MK-1775	0.5255
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (No)	GDSC	BI-2536	0.1372
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (No)	GDSC	GW843682X	0.0477
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (No)	GDSC	PLK_6522	0.0989
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (No)	GDSC	MK-1775	0.3687
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	BI-2536	0.4894
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	GW843682X	0.1977
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	PLK_6522	0.0601
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	PLK_6522	0.0219
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	BI-2536	4.4982
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	MK-1775	3.2182
SIDM00444	ESCA\|oesophagus	p.R557W (No)	GDSC	PLK_6522	0.5422
SIDM00444	ESCA\|oesophagus	p.R557W (No)	GDSC	MK-1775	0.9648
SIDM00611	KIRC\|kidney	p.R354H (No)	GDSC	PLK_6522	0.3272
SIDM00611	KIRC\|kidney	p.R354H (No)	GDSC	MK-1775	15.688
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	BI-2536	0.0311
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	GW843682X	0.0298
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	PLK_6522	0.0888
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	MK-1775	54.604
SIDM00537	COREAD\|large_intestine	p.G238W (No)	GDSC	PLK_6522	0.0263
SIDM00537	COREAD\|large_intestine	p.G238W (No)	GDSC	MK-1775	0.7137
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	PLK_6522	9.8996
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	BI-2536	18.254
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	MK-1775	149.22
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	BI-2536	0.7804
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	GW843682X	0.4615
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	PLK_6522	0.0161
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	MK-1775	0.9944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RLILYND

Degron related mutations and impact score

Drug responses associated with PLK1 mutations

All proteins holding degron of RLILYND

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53350	Serine/threonine-protein kinase PLK1	LIG_APCC_ABBAyCdc20_2	441:447	RLILYND	APC,CDC20,FZR1	0.7467	More...