DegronMD

Uniprot ID: Q9UHG2

Source protein: ProSAAS

Source gene: PCSK1N

Class: LIG_APCC_ABBAyCdc20_2

Location: 167:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9346

ASA_SCORE: 92.5714

COIL: 0.9136

CONS_SCORE: 0.978

DSS_SCORE: 0.6594

HELIX: 0.0199

FCONS_SCORE: 1.184

RIG_SCORE: 0.6268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A157T	DO50970	LICA	ICGC	RPPVYDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A157V	ACH-000627	Lung Cancer	CCLE	RPPVYDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A163V	ACH-002026	Endometrial/Uterine Cancer	CCLE	RPPVYDD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHG2	ProSAAS	LIG_APCC_ABBAyCdc20_2	167:173	RPPVYDD	APC,CDC20,FZR1	0.9346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons