DegronMD

Uniprot ID: P13056

Source protein: Nuclear receptor subfamily 2 group C member 1

Source gene: NR2C1

Class: DEG_SCF_SKP2-CKS1_1

Location: 61:68

E3 ligase: SKP2,CSK1

DEGRON score: 0.9564

ASA_SCORE: 93.4875

COIL: 0.8596

CONS_SCORE: 0.4983

DSS_SCORE: 0.3827

HELIX: 0.0191

FCONS_SCORE: 0.966

RIG_SCORE: 0.7148

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P74S	TCGA-D1-A103	UCEC	TCGA	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P74S	DO42312	UCEC	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P66L	TCGA-EE-A2MQ	SKCM	TCGA	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P66L	DO227994	COCA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P66L	DO37810	SKCM	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7582
p.G51S	DO234167	ESAD	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM01176	B-Lymphoblastic Leukemia	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM00670	Pancreatic Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM00310	Mesothelioma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G51S	SIDM01480	Ovarian Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T72K	DO228948	LICA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T65N	DO228976	LICA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7055
p.Q62K	DO228986	LICA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.5833
p.Q62K	DO229038	LICA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68E	DO229047	LICA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00781	Colorectal Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00291	Melanoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00281	Other Solid Cancers	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00562	Breast Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01210	Glioblastoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01393	Gastric Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01394	Kidney Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM00780	Colorectal Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01494	Glioblastoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01694	B-Lymphoblastic Leukemia	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01451	Pancreatic Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68E	SIDM01442	Glioma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.P66S	DO219878	SKCA	ICGC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6752
p.L59V	SIDM00414	Bladder Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.L59V	ACH-000545	Bladder Cancer	CCLE	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.L59V	VM-CUB-1	urinary_tract	COSMIC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.T72A	SIDM00537	Colorectal Carcinoma	GDSC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T72A	ACH-000982	Colon/Colorectal Cancer	CCLE	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T72A	ACH-001345	Colon/Colorectal Cancer	CCLE	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T72A	GP5d	large_intestine	COSMIC	RQDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RQDSTPGK

Degron related mutations and impact score

Drug responses associated with NR2C1 mutations

All proteins holding degron of RQDSTPGK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13056	Nuclear receptor subfamily 2 group C member 1	DEG_SCF_SKP2-CKS1_1	61:68	RQDSTPGK	SKP2,CSK1	0.9564	More...