DegronMD

Uniprot ID: O14893

Source protein: Gem-associated protein 2

Source gene: GEMIN2

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7801

ASA_SCORE: 108.4778

COIL: 0.7833

CONS_SCORE: 0.2895

DSS_SCORE: 0.5001

HELIX: 0.1483

FCONS_SCORE: 0.9371

RIG_SCORE: 0.772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M12I	DO229045	LICA	ICGC	RRAELAGLK	DEG_APCC_DBOX_1	0.2778
p.W14R	SIDM00282	Colorectal Carcinoma	GDSC	RRAELAGLK	DEG_APCC_DBOX_1	0.2222
p.W14R	ACH-000998	Colon/Colorectal Cancer	CCLE	RRAELAGLK	DEG_APCC_DBOX_1	0.2222
p.W14R	CW-2	large_intestine	COSMIC	RRAELAGLK	DEG_APCC_DBOX_1	0.2222
p.A17T	ACH-001656	Leukemia	CCLE	RRAELAGLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14893	Gem-associated protein 2	DEG_APCC_DBOX_1	2:10	RRAELAGLK	APC,CDC20,FZR1	0.7801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons