DegronMD

Uniprot ID: Q96MC4

Source protein: CEP295 N-terminal-like protein

Source gene: CEP295NL

Class: DEG_APCC_DBOX_1

Location: 546:554

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8693

ASA_SCORE: 121.8222

COIL: 0.2769

CONS_SCORE: 0.8821

DSS_SCORE: 0.6183

HELIX: 0.7286

FCONS_SCORE: 1.1623

RIG_SCORE: 0.6969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q545K	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRARLAHLK	DEG_APCC_DBOX_1	0.3056
p.Q545K	NCI-H2172	lung	COSMIC	RRARLAHLK	DEG_APCC_DBOX_1	0.3056
p.E539D	SIDM00302	Other Solid Cancers	GDSC	RRARLAHLK	DEG_APCC_DBOX_1	0.1389
p.E539D	KGN	ovary	COSMIC	RRARLAHLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MC4	CEP295 N-terminal-like protein	DEG_APCC_DBOX_1	546:554	RRARLAHLK	APC,CDC20,FZR1	0.8693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons