DegronMD

Uniprot ID: A6NJW9

Source protein: T-cell surface glycoprotein CD8 beta-2 chain

Source gene: CD8B2

Class: DEG_APCC_DBOX_1

Location: 198:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5191

ASA_SCORE: 129.0889

COIL: 0.653

CONS_SCORE: 0.7179

DSS_SCORE: 0.1261

HELIX: 0.29

FCONS_SCORE: 1.2377

RIG_SCORE: 0.9066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G188A	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	RRARLRFMK	DEG_APCC_DBOX_1	0.0556
p.G188V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	RRARLRFMK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NJW9	T-cell surface glycoprotein CD8 beta-2 chain	DEG_APCC_DBOX_1	198:206	RRARLRFMK	APC,CDC20,FZR1	0.5191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons