DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RRASLPSLS
Uniprot ID:
Q8IX06
Source protein:
Putative exonuclease GOR
Source gene:
REXO1L1P
Class:
DEG_APCC_DBOX_1
Location:
270:278
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6959
ASA_SCORE:
97.5
COIL:
0.8569
CONS_SCORE:
0.2385
DSS_SCORE:
0.3697
HELIX:
0.0846
FCONS_SCORE:
0.939
RIG_SCORE:
0.7718
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with REXO1L1P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRASLPSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IX06
Putative exonuclease GOR
DEG_APCC_DBOX_1
270:278
RRASLPSLS
APC,CDC20,FZR1
0.6959
More...