DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
RRCRLLRVP
Uniprot ID:
A6NLJ0
Source protein:
C2 calcium-dependent domain-containing protein 4B
Source gene:
C2CD4B
Class:
DEG_APCC_DBOX_1
Location:
172:180
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8351
ASA_SCORE:
95.7444
COIL:
0.7599
CONS_SCORE:
0.7736
DSS_SCORE:
0.3734
HELIX:
0.1521
FCONS_SCORE:
1.3776
RIG_SCORE:
0.8046
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R189Q
DO233867
GACA
ICGC
RRCRLLRVP
DEG_APCC_DBOX_1
0.0833
p.A187V
ACH-002059
Leukemia
CCLE
RRCRLLRVP
DEG_APCC_DBOX_1
0.1389
Drug responses associated with C2CD4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRCRLLRVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NLJ0
C2 calcium-dependent domain-containing protein 4B
DEG_APCC_DBOX_1
172:180
RRCRLLRVP
APC,CDC20,FZR1
0.8351
More...