DegronMD

Uniprot ID: Q13751

Source protein: Laminin subunit beta-3

Source gene: LAMB3

Class: DEG_APCC_DBOX_1

Location: 112:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6835

ASA_SCORE: 52.1889

COIL: 0.2209

CONS_SCORE: 0.7737

DSS_SCORE: 0.2731

HELIX: 0.0027

FCONS_SCORE: 0.9511

RIG_SCORE: 0.8544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A129T	TCGA-23-1122	OV	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.0833
p.A129T	DO30570	OV	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.0833
p.A129T	DO232761	PBCA	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.0833
p.M127I	TCGA-A5-A0G2	UCEC	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.1389
p.M127I	DO41235	UCEC	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.1389
p.P128S	TCGA-AX-A06F	UCEC	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.1111
p.P128S	DO41752	UCEC	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.1111
p.G130D	TCGA-CA-6717	COAD	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.0556
p.G130D	DO8264	COAD	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.0556
p.Q117H	TCGA-D9-A6EC	SKCM	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.647
p.Q117H	DO50291	SKCM	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.647
p.Q115H	TCGA-DF-A2KU	UCEC	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.647
p.Q115H	DO223286	UCEC	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.647
p.R112M	TCGA-ER-A19P	SKCM	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.7521
p.R112M	DO47623	SKCM	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.7521
p.Q107H	TCGA-VQ-A91D	STAD	TCGA	RRFQLQEVM	DEG_APCC_DBOX_1	0.1944
p.Q107H	DO51783	STAD	ICGC	RRFQLQEVM	DEG_APCC_DBOX_1	0.1944
p.D111G	SIDM01265	Plasma Cell Myeloma	GDSC	RRFQLQEVM	DEG_APCC_DBOX_1	0.3056
p.M120T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	RRFQLQEVM	DEG_APCC_DBOX_1	0.6312
p.M120T	ACH-000938	Leukemia	CCLE	RRFQLQEVM	DEG_APCC_DBOX_1	0.6312
p.M120T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	RRFQLQEVM	DEG_APCC_DBOX_1	0.6312
p.V104L	SIDM00498	Colorectal Carcinoma	GDSC	RRFQLQEVM	DEG_APCC_DBOX_1	0.1111
p.V104L	ACH-000970	Colon/Colorectal Cancer	CCLE	RRFQLQEVM	DEG_APCC_DBOX_1	0.1111
p.V104L	SNU-C5	large_intestine	COSMIC	RRFQLQEVM	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13751	Laminin subunit beta-3	DEG_APCC_DBOX_1	112:120	RRFQLQEVM	APC,CDC20,FZR1	0.6835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons