DegronMD

Uniprot ID: Q5JSJ4

Source protein: Integrator complex subunit 6-like

Source gene: INTS6L

Class: DEG_APCC_DBOX_1

Location: 517:525

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5405

ASA_SCORE: 54.7667

COIL: 0.0768

CONS_SCORE: 0.4493

DSS_SCORE: 0.266

HELIX: 0.9234

FCONS_SCORE: 1.0532

RIG_SCORE: 0.8277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L521F	HCC-366	lung	COSMIC	RRGLLDQLT	DEG_APCC_DBOX_1	0.6981
p.P516S	SW684	soft_tissue	COSMIC	RRGLLDQLT	DEG_APCC_DBOX_1	0.3056
p.Y509C	CAL-78	bone	COSMIC	RRGLLDQLT	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSJ4	Integrator complex subunit 6-like	DEG_APCC_DBOX_1	517:525	RRGLLDQLT	APC,CDC20,FZR1	0.5405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons