DegronMD

Uniprot ID: Q8WUM0

Source protein: Nuclear pore complex protein Nup133

Source gene: NUP133

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9537

ASA_SCORE: 88.1778

COIL: 0.951

CONS_SCORE: 0.2575

DSS_SCORE: 0.7847

HELIX: 0.0257

FCONS_SCORE: 0.8309

RIG_SCORE: 0.577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P29S	TCGA-98-A53A	LUSC	TCGA	RRGPLAGLG	DEG_APCC_DBOX_1	0.1944
p.T13S	TCGA-HU-A4G9	STAD	TCGA	RRGPLAGLG	DEG_APCC_DBOX_1	0.6944
p.T13S	DO47789	STAD	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.6944
p.G24W	DO20784	KIRP	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.6714
p.P30T	DO229029	LICA	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.1667
p.P13S	DO219178	LUSC	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.6944
p.G20C	DO28731	OV	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.76
p.S28C	DO229218	THCA	ICGC	RRGPLAGLG	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUM0	Nuclear pore complex protein Nup133	DEG_APCC_DBOX_1	16:24	RRGPLAGLG	APC,CDC20,FZR1	0.9537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons