DegronMD

Uniprot ID: P35555

Source protein: Fibrillin-1 [Cleaved into: Asprosin]

Source gene: FBN1

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7397

ASA_SCORE: 78.4444

COIL: 0.4906

CONS_SCORE: 0.483

DSS_SCORE: 0.2885

HELIX: 0.0098

FCONS_SCORE: 1.0447

RIG_SCORE: 0.8634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A10T	TCGA-BR-4184	STAD	TCGA	RRGRLLEIA	DEG_APCC_DBOX_1	0.6028
p.A10T	DO38328	STAD	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.6028
p.R5C	TCGA-BR-8591	STAD	TCGA	RRGRLLEIA	DEG_APCC_DBOX_1	0.719
p.R5C	DO47973	STAD	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.719
p.R5H	TCGA-CK-5913	COAD	TCGA	RRGRLLEIA	DEG_APCC_DBOX_1	0.7133
p.R5H	DO8826	COAD	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.7133
p.R2C	TCGA-HU-A4GQ	STAD	TCGA	RRGRLLEIA	DEG_APCC_DBOX_1	0.719
p.R2C	DO47767	STAD	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.719
p.S19F	TCGA-QK-A8Z8	HNSC	TCGA	RRGRLLEIA	DEG_APCC_DBOX_1	0.0833
p.S19F	DO52097	HNSC	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.0833
p.L16I	DO229006	LICA	ICGC	RRGRLLEIA	DEG_APCC_DBOX_1	0.1667
p.Y20C	SIDM01132	Other Solid Cancers	GDSC	RRGRLLEIA	DEG_APCC_DBOX_1	0.0556
p.Y20C	PFSK-1	central_nervous_system	COSMIC	RRGRLLEIA	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35555	Fibrillin-1 [Cleaved into: Asprosin]	DEG_APCC_DBOX_1	2:10	RRGRLLEIA	APC,CDC20,FZR1	0.7397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons