DegronMD

Uniprot ID: P57059

Source protein: Serine/threonine-protein kinase SIK1

Source gene: SIK1

Class: DEG_APCC_DBOX_1

Location: 470:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9997

ASA_SCORE: 103.2556

COIL: 0.7881

CONS_SCORE: 0.4268

DSS_SCORE: 0.6057

HELIX: 0.1692

FCONS_SCORE: 1.4106

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A486V	TCGA-B5-A3FC	UCEC	TCGA	RRHTLAEVS	DEG_APCC_DBOX_1	0.1111
p.A486V	DO230326	COCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.1111
p.A486V	DO41871	UCEC	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.1111
p.R470Q	TCGA-VS-A9U6	CESC	TCGA	RRHTLAEVS	DEG_APCC_DBOX_1	0.6218
p.R470Q	DO219728	CESC	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.6218
p.T479P	DO222499	BTCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.75
p.T479P	DO229188	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.75
p.T479P	DO229103	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.75
p.T479P	DO229084	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.75
p.R480H	DO50437	ESAD	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.2778
p.R480H	DO231997	ORCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.2778
p.L484I	DO220873	MELA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.1667
p.T460M	DO232761	PBCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.5
p.T460S	DO229221	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.5
p.S467G	DO229234	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.25
p.C488F	DO229245	THCA	ICGC	RRHTLAEVS	DEG_APCC_DBOX_1	0.0556
p.G469C	ACH-000997	Colon/Colorectal Cancer	CCLE	RRHTLAEVS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57059	Serine/threonine-protein kinase SIK1	DEG_APCC_DBOX_1	470:478	RRHTLAEVS	APC,CDC20,FZR1	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons