DegronMD

Uniprot ID: Q9H410

Source protein: Kinetochore-associated protein DSN1 homolog

Source gene: DSN1

Class: DEG_APCC_DBOX_1

Location: 106:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 88.0111

COIL: 0.7798

CONS_SCORE: 0.6

DSS_SCORE: 0.5258

HELIX: 0.0976

FCONS_SCORE: 1.0737

RIG_SCORE: 0.6784

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S109L	TCGA-06-1802	GBM	TCGA	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	TCGA-B5-A11J	UCEC	TCGA	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	DO12100	GBM	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	DO43698	UCEC	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	SIDM00889	Cervical Carcinoma	GDSC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	ACH-001333	Cervical Cancer	CCLE	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.S109L	C-33-A	cervix	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7667
p.G109R	NCI-H1793	lung	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7568
p.R107Q	SIDM00848	Ewing's Sarcoma	GDSC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7329
p.R107Q	ACH-000052	Bone Cancer	CCLE	RRKSLHPIH	DEG_APCC_DBOX_1	0.7329
p.R107Q	A673	bone	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7329
p.E111K	Mewo	skin	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.7022
p.P112H	TCGA-AZ-4615	COAD	TCGA	RRKSLHPIH	DEG_APCC_DBOX_1	0.6583
p.P112H	DO7977	COAD	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.6583
p.R106Q	ACH-000975	Lung Cancer	CCLE	RRKSLHPIH	DEG_APCC_DBOX_1	0.6218
p.A102T	COLO-824	breast	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.3333
p.T104M	TCGA-DF-A2KU	UCEC	TCGA	RRKSLHPIH	DEG_APCC_DBOX_1	0.2778
p.T104M	DO223286	UCEC	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.2778
p.L120V	DO228126	EOPC	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.1667
p.A99E	DO229029	LICA	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.1389
p.L99V	NCI-H1573	lung	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.1389
p.R97W	DO232761	PBCA	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.0833
p.I124L	TCGA-VG-A8LO	OV	TCGA	RRKSLHPIH	DEG_APCC_DBOX_1	0.0556
p.I124L	DO50656	OV	ICGC	RRKSLHPIH	DEG_APCC_DBOX_1	0.0556
p.S96T	CP67-MEL	skin	COSMIC	RRKSLHPIH	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H410	Kinetochore-associated protein DSN1 homolog	DEG_APCC_DBOX_1	106:114	RRKSLHPIH	APC,CDC20,FZR1	0.9956	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons