DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_APCC_DBOX_1

Location: 3809:3817

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6191

ASA_SCORE: 28.2

COIL: 0.1102

CONS_SCORE: 0.8399

DSS_SCORE: 0.0726

HELIX: 0.878

FCONS_SCORE: 1.3317

RIG_SCORE: 0.9277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3826V	TCGA-A2-A0YK	BRCA	TCGA	RRLFLQLML	DEG_APCC_DBOX_1	0.0833
p.L3826V	DO2836	BRCA	ICGC	RRLFLQLML	DEG_APCC_DBOX_1	0.0833
p.F3807L	DO222762	COCA	ICGC	RRLFLQLML	DEG_APCC_DBOX_1	0.2778
p.L3813S	SIDM00545	Melanoma	GDSC	RRLFLQLML	DEG_APCC_DBOX_1	0.7667
p.L3813S	ACH-000987	Skin Cancer	CCLE	RRLFLQLML	DEG_APCC_DBOX_1	0.7667
p.L3813S	Mewo	skin	COSMIC	RRLFLQLML	DEG_APCC_DBOX_1	0.7667
p.K3821I	SIDM00049	Colorectal Carcinoma	GDSC	RRLFLQLML	DEG_APCC_DBOX_1	0.3333
p.K3821I	ACH-002233	Colon/Colorectal Cancer	CCLE	RRLFLQLML	DEG_APCC_DBOX_1	0.3333
p.K3821I	DIFI	large_intestine	COSMIC	RRLFLQLML	DEG_APCC_DBOX_1	0.3333
p.F3825S	SIDM00053	Pancreatic Carcinoma	GDSC	RRLFLQLML	DEG_APCC_DBOX_1	0.1111
p.F3825S	ACH-002164	Pancreatic Cancer	CCLE	RRLFLQLML	DEG_APCC_DBOX_1	0.1111
p.F3825S	MZ1-PC	pancreas	COSMIC	RRLFLQLML	DEG_APCC_DBOX_1	0.1111
p.R3810T	ACH-002511	Skin Cancer	CCLE	RRLFLQLML	DEG_APCC_DBOX_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_APCC_DBOX_1	3809:3817	RRLFLQLML	APC,CDC20,FZR1	0.6191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons