DegronMD

Uniprot ID: Q9HBL8

Source protein: NmrA-like family domain-containing protein 1

Source gene: NMRAL1

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5545

ASA_SCORE: 53.9

COIL: 0.4182

CONS_SCORE: 0.6627

DSS_SCORE: 0.0322

HELIX: 0.2484

FCONS_SCORE: 1.2941

RIG_SCORE: 0.8824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I117V	TCGA-BR-8487	STAD	TCGA	RRLGLHYVV	DEG_APCC_DBOX_1	0.1389
p.I117V	DO47867	STAD	ICGC	RRLGLHYVV	DEG_APCC_DBOX_1	0.1389
p.A98T	TCGA-D1-A103	UCEC	TCGA	RRLGLHYVV	DEG_APCC_DBOX_1	0.2222
p.A98T	DO42312	UCEC	ICGC	RRLGLHYVV	DEG_APCC_DBOX_1	0.2222
p.A101S	TCGA-HE-7130	KIRP	TCGA	RRLGLHYVV	DEG_APCC_DBOX_1	0.3056
p.A101S	DO20776	KIRP	ICGC	RRLGLHYVV	DEG_APCC_DBOX_1	0.3056
p.R103H	SIDM00789	Colorectal Carcinoma	GDSC	RRLGLHYVV	DEG_APCC_DBOX_1	0.8244
p.R103H	ACH-000997	Colon/Colorectal Cancer	CCLE	RRLGLHYVV	DEG_APCC_DBOX_1	0.8244
p.R103H	ACH-001061	Colon/Colorectal Cancer	CCLE	RRLGLHYVV	DEG_APCC_DBOX_1	0.8244
p.R103H	HCT-15	large_intestine	COSMIC	RRLGLHYVV	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBL8	NmrA-like family domain-containing protein 1	DEG_APCC_DBOX_1	102:110	RRLGLHYVV	APC,CDC20,FZR1	0.5545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons