DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRLTLHSVF
Uniprot ID:
Q6ZMZ0
Source protein:
E3 ubiquitin-protein ligase RNF19B
Source gene:
RNF19B
Class:
DEG_APCC_DBOX_1
Location:
31:39
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6571
ASA_SCORE:
80.1333
COIL:
0.4787
CONS_SCORE:
0.3036
DSS_SCORE:
0.6362
HELIX:
0.4704
FCONS_SCORE:
1.0123
RIG_SCORE:
0.7156
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A43T
DO222404
BTCA
ICGC
RRLTLHSVF
DEG_APCC_DBOX_1
0.2222
p.R31Q
DO229232
THCA
ICGC
RRLTLHSVF
DEG_APCC_DBOX_1
0.6218
Drug responses associated with RNF19B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRLTLHSVF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZMZ0
E3 ubiquitin-protein ligase RNF19B
DEG_APCC_DBOX_1
31:39
RRLTLHSVF
APC,CDC20,FZR1
0.6571
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