DegronMD

Uniprot ID: P31260

Source protein: Homeobox protein Hox-A10

Source gene: HOXA10

Class: DEG_APCC_DBOX_1

Location: 387:395

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6112

ASA_SCORE: 117.5667

COIL: 0.5553

CONS_SCORE: 0.758

DSS_SCORE: 0.2995

HELIX: 0.3894

FCONS_SCORE: 1.1519

RIG_SCORE: 0.8323

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K392Q	TCGA-CK-6746	COAD	TCGA	RRMKLKKMN	DEG_APCC_DBOX_1	0.5833
p.K392N	TCGA-AP-A1DV	UCEC	TCGA	RRMKLKKMN	DEG_APCC_DBOX_1	0.5806
p.R396G	TCGA-A5-A0G1	UCEC	TCGA	RRMKLKKMN	DEG_APCC_DBOX_1	0.3056
p.E402D	TCGA-G2-AA3B	BLCA	TCGA	RRMKLKKMN	DEG_APCC_DBOX_1	0.1389
p.R378K	TCGA-G2-A3VY	BLCA	TCGA	RRMKLKKMN	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31260	Homeobox protein Hox-A10	DEG_APCC_DBOX_1	387:395	RRMKLKKMN	APC,CDC20,FZR1	0.6112	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons