DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRPPLRRMP
Uniprot ID:
A6NI87
Source protein:
Protein chibby homolog 3
Source gene:
CBY3
Class:
DEG_APCC_DBOX_1
Location:
91:99
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8016
ASA_SCORE:
105.3333
COIL:
0.9364
CONS_SCORE:
0.3301
DSS_SCORE:
0.3826
HELIX:
0.029
FCONS_SCORE:
0.5743
RIG_SCORE:
0.6888
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S85L
DO227976
COCA
ICGC
RRPPLRRMP
DEG_APCC_DBOX_1
0.1667
Drug responses associated with CBY3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRPPLRRMP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NI87
Protein chibby homolog 3
DEG_APCC_DBOX_1
91:99
RRPPLRRMP
APC,CDC20,FZR1
0.8016
More...