DegronMD

Uniprot ID: P07949

Source protein: Proto-oncogene tyrosine-protein kinase receptor Ret

Source gene: RET

Class: DEG_APCC_DBOX_1

Location: 693:701

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7984

ASA_SCORE: 87.9556

COIL: 0.737

CONS_SCORE: 0.3633

DSS_SCORE: 0.4414

HELIX: 0.1776

FCONS_SCORE: 1.0684

RIG_SCORE: 0.6614

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R693C	TCGA-2W-A8YY	CESC	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.719
p.R693C	DO223732	CESC	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.719
p.V706M	TCGA-AA-A022	COAD	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.1944
p.V706M	TCGA-CD-A48C	STAD	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.1944
p.V706M	DO10647	COAD	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.1944
p.V706M	DO233089	GACA	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.1944
p.V706M	DO47912	STAD	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.1944
p.V685I	TCGA-EE-A29D	SKCM	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.1111
p.V685I	DO38123	SKCM	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.1111
p.V685I	ACH-001651	Endometrial/Uterine Cancer	CCLE	RRPSLDSME	DEG_APCC_DBOX_1	0.1111
p.D698N	TCGA-FW-A3TV	SKCM	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.5821
p.D698N	DO38159	SKCM	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.5821
p.Q703H	TCGA-G5-6641	READ	TCGA	RRPSLDSME	DEG_APCC_DBOX_1	0.2778
p.Q703H	DO36909	READ	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.2778
p.G691S	DO228483	BRCA	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.2778
p.G691S	DO229505	LAML	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.2778
p.G691S	DO231207	LUSC	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.2778
p.S686I	DO228974	LICA	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.5833
p.S705F	DO229446	SKCA	ICGC	RRPSLDSME	DEG_APCC_DBOX_1	0.6667
p.S688F	SIDM00007	Other Solid Cancers	GDSC	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.S688F	ACH-001550	Skin Cancer	CCLE	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.S688F	MCC13	skin	COSMIC	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.S688Y	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.S688Y	ACH-000843	Lung Cancer	CCLE	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.S688Y	HARA	lung	COSMIC	RRPSLDSME	DEG_APCC_DBOX_1	0.6389
p.P695A	SIDM01045	Endometrial Carcinoma	GDSC	RRPSLDSME	DEG_APCC_DBOX_1	0.6392
p.P695A	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRPSLDSME	DEG_APCC_DBOX_1	0.6392
p.P695A	EN	endometrium	COSMIC	RRPSLDSME	DEG_APCC_DBOX_1	0.6392
p.R693H	ACH-000333	Ovarian Cancer	CCLE	RRPSLDSME	DEG_APCC_DBOX_1	0.7133

Drug responses associated with RET mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.A498V (No)	GDSC	Cabozantinib	17.7563
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.A498V (No)	GDSC	Motesanib	18.0767
SIDM01024	ESCA\|oesophagus	p.A217V (No)	GDSC	Cabozantinib	76.1936
SIDM01024	ESCA\|oesophagus	p.A217V (No)	GDSC	Motesanib	3.5405
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Sunitinib	1.7779
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Cabozantinib	2.3117
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Motesanib	4.4666
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Sunitinib	88.7242
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Cabozantinib	16.91
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Motesanib	30.5258
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	XMD11-85h	33.3957
SIDM00151	OV\|ovary	p.A750T (No)	GDSC	Motesanib	51.1276
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	Cabozantinib	14.3805
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	Motesanib	30.941
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	XMD11-85h	153.9933
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	Cabozantinib	14.3805
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	Motesanib	30.941
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	XMD11-85h	153.9933
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	XMD11-85h	27.4782
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	XMD11-85h	27.4782
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	XMD11-85h	27.4782
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Sunitinib	11.6783
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Cabozantinib	9.1978
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Motesanib	10.4
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	XMD11-85h	36.8239
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Sunitinib	20.9013
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Cabozantinib	23.515
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Motesanib	3.309
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	XMD11-85h	78.469
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	XMD11-85h	78.469
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	XMD11-85h	78.469
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	Cabozantinib	8.1118
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	Motesanib	21.4294
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	XMD11-85h	193.5587
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Sunitinib	22.4386
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Cabozantinib	170.0174
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Motesanib	21.6739
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	XMD11-85h	280.243
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Motesanib	12.841
SIDM00091	OV\|ovary	p.R79Q (No)	GDSC	Cabozantinib	29.573
SIDM00091	OV\|ovary	p.R79Q (No)	GDSC	Motesanib	4.5718
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Sunitinib	104.5319
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Cabozantinib	27.7034
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Motesanib	7.5897
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	XMD11-85h	92.7316
SIDM00945	COREAD\|large_intestine	p.R77H (No)	GDSC	Motesanib	53.4553
SIDM00945	COREAD\|large_intestine	p.R77H (No)	GDSC	XMD11-85h	204.9445
SIDM00945	COREAD\|large_intestine	p.V438I (No)	GDSC	Motesanib	53.4553
SIDM00945	COREAD\|large_intestine	p.V438I (No)	GDSC	XMD11-85h	204.9445
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Sunitinib	9.3767
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Cabozantinib	6.525
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Motesanib	26.0901
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	Cabozantinib	60.0418
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	Motesanib	2.6458
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	XMD11-85h	333.7953
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S853T (No)	GDSC	Motesanib	16.8754
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S853T (No)	GDSC	XMD11-85h	328.3027
SIDM01237	LIHC\|liver	p.D567N (No)	GDSC	Cabozantinib	82.098
SIDM01237	LIHC\|liver	p.D567N (No)	GDSC	Motesanib	16.4376
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Sunitinib	5.8574
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Cabozantinib	4.4868
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Motesanib	21.9259
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	Cabozantinib	40.1612
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	Motesanib	3.8845
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	XMD11-85h	41.4783
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	Cabozantinib	7.7925
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	Motesanib	3.2422
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	XMD11-85h	133.7068
SIDM01045	UCEC\|endometrium	p.P695A (Yes)	GDSC	Cabozantinib	11.3765
SIDM01045	UCEC\|endometrium	p.P695A (Yes)	GDSC	Motesanib	50.6745
SIDM01045	UCEC\|endometrium	p.P695A (Yes)	GDSC	XMD11-85h	219.324
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Sunitinib	3.1015
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Cabozantinib	8.6717
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Motesanib	15.3786
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	XMD11-85h	10.4455
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Sunitinib	3.1015
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Cabozantinib	8.6717
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Motesanib	15.3786
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	XMD11-85h	10.4455
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Sunitinib	4.978
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Cabozantinib	2.1053
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Motesanib	8.8402
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	XMD11-85h	24.8078
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (Yes)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (Yes)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (Yes)	GDSC	XMD11-85h	24.8078
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	XMD11-85h	24.8078
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	Cabozantinib	58.3136
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	Motesanib	11.1263
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	XMD11-85h	85.4102
SIDM00217	COREAD\|large_intestine	p.L318M (No)	GDSC	Cabozantinib	12.0756
SIDM00216	COREAD\|large_intestine	p.T1038A (No)	GDSC	Cabozantinib	6.0987
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	Cabozantinib	46.7809
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	Motesanib	11.7321
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	XMD11-85h	75.0552
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Sunitinib	189.499
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Cabozantinib	55.7164
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Motesanib	57.5889
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	XMD11-85h	133.3314
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Sunitinib	13.6015
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Cabozantinib	75.8238
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Motesanib	32.9845
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	XMD11-85h	60.6134
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Sunitinib	13.6015
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Cabozantinib	75.8238
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Motesanib	32.9845
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	XMD11-85h	60.6134
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N151S (No)	GDSC	Sunitinib	35.5508
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N151S (No)	GDSC	Cabozantinib	36.5642
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Sunitinib	10.3118
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Motesanib	31.3099
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	XMD11-85h	7.9834
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	XMD11-85h	7.9834
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	XMD11-85h	7.9834
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.A281V (No)	GDSC	Cabozantinib	43.6646
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.A281V (No)	GDSC	Motesanib	28.8326
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Sunitinib	135.0418
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Cabozantinib	80.591
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Motesanib	42.2863
SIDM00375	HNSC\|head_and_neck	p.T278N (No)	GDSC	Cabozantinib	51.7016
SIDM00375	HNSC\|head_and_neck	p.T278N (No)	GDSC	Motesanib	27.3106
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Sunitinib	67.6818
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Cabozantinib	8.7434
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Motesanib	9.8384
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	XMD11-85h	31.8841
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	Cabozantinib	14.2209
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	Motesanib	12.7822
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	XMD11-85h	138.9371
SIDM00336	SKCM\|melanoma	p.S765F (No)	GDSC	Cabozantinib	9.192
SIDM00336	SKCM\|melanoma	p.S765F (No)	GDSC	Motesanib	4.5686
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	Cabozantinib	53.686
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	Motesanib	12.5075
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	XMD11-85h	9.0863
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Sunitinib	9.6747
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Cabozantinib	3.557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Motesanib	14.2029
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	Cabozantinib	5.6829
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	Motesanib	8.6977
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	XMD11-85h	48.4976
SIDM00545	SKCM\|melanoma	p.Y791F (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.Y791F (No)	GDSC	Motesanib	13.0462
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Sunitinib	1.1173
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Cabozantinib	0.3851
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Motesanib	11.0276
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	XMD11-85h	9.7208
SIDM00120	PRAD\|prostate	p.L746M (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.L746M (No)	GDSC	Motesanib	0.5405
SIDM00120	PRAD\|prostate	p.V804M (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.V804M (No)	GDSC	Motesanib	0.5405
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Sunitinib	7.1072
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Cabozantinib	9.3916
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Motesanib	12.7086
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	XMD11-85h	55.7544
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	Cabozantinib	4.8518
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	Motesanib	10.448
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	XMD11-85h	18.6178
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	Cabozantinib	4.8518
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	Motesanib	10.448
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	XMD11-85h	18.6178
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G828R (No)	GDSC	Motesanib	18.3463
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Sunitinib	4.5073
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Cabozantinib	23.0587
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Motesanib	27.8266
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	XMD11-85h	55.5189
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	Cabozantinib	68.3794
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	Motesanib	25.0231
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	XMD11-85h	67.6917
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Sunitinib	35.0209
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Cabozantinib	21.8214
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Motesanib	17.8326
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Sunitinib	15.6838
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Cabozantinib	2.2748
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Motesanib	14.1657
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Sunitinib	11.0351
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Cabozantinib	9.9816
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Motesanib	27.4647
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	XMD11-85h	20.6871
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	Cabozantinib	10.026
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	Motesanib	10.5828
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	XMD11-85h	15.5664
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Sunitinib	67.5213
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Motesanib	15.5156
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Sunitinib	67.5213
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Motesanib	15.5156
SIDM01062	BRCA\|breast	p.D567N (No)	GDSC	Cabozantinib	58.1103
SIDM01062	BRCA\|breast	p.D567N (No)	GDSC	Motesanib	32.9998
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	Motesanib	11.224
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	XMD11-85h	91.4281
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	Motesanib	11.224
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	XMD11-85h	91.4281
SIDM00693	BLCA\|bladder	p.F1112Y (No)	GDSC	Cabozantinib	32.8868
SIDM00693	BLCA\|bladder	p.F1112Y (No)	GDSC	Motesanib	6.5109
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	Motesanib	50.1977
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	XMD11-85h	111.2169
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Sunitinib	6.1015
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Cabozantinib	6.1357
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Motesanib	19.4607
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	XMD11-85h	227.5218

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRPSLDSME

Degron related mutations and impact score

Drug responses associated with RET mutations

All proteins holding degron of RRPSLDSME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	DEG_APCC_DBOX_1	693:701	RRPSLDSME	APC,CDC20,FZR1	0.7984	More...