DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.912

ASA_SCORE: 86.3222

COIL: 0.5916

CONS_SCORE: 0.4307

DSS_SCORE: 0.4836

HELIX: 0.0392

FCONS_SCORE: 1.0045

RIG_SCORE: 0.7404

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P452L	DO218874	SKCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.6471
p.S464L	TCGA-98-A53B	LUSC	TCGA	RRPTLAWLE	DEG_APCC_DBOX_1	0.6111
p.S464L	TCGA-DK-A6B6	BLCA	TCGA	RRPTLAWLE	DEG_APCC_DBOX_1	0.6111
p.S464L	DO48576	BLCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.6111
p.S464L	DO52023	LUSC	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.6111
p.D448N	TCGA-G2-A2EF	BLCA	TCGA	RRPTLAWLE	DEG_APCC_DBOX_1	0.2778
p.D448N	DO726	BLCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.2778
p.S461C	TCGA-DK-A6B6	BLCA	TCGA	RRPTLAWLE	DEG_APCC_DBOX_1	0.25
p.S461C	DO48576	BLCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.25
p.K468I	DO222637	BTCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.1667
p.I466M	DO217826	BRCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.1111
p.I466M	DO1108	BRCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.1111
p.S440L	TCGA-E5-A4U1	BLCA	TCGA	RRPTLAWLE	DEG_APCC_DBOX_1	0.0556
p.S440L	DO44061	BLCA	ICGC	RRPTLAWLE	DEG_APCC_DBOX_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_APCC_DBOX_1	450:458	RRPTLAWLE	APC,CDC20,FZR1	0.912	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons