DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RRRKLRRLN
Uniprot ID:
A8MQ11
Source protein:
Postmeiotic segregation increased 2-like protein 5
Source gene:
PMS2P5
Class:
DEG_APCC_DBOX_1
Location:
4:12
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8321
ASA_SCORE:
78.4778
COIL:
0.5716
CONS_SCORE:
0
DSS_SCORE:
0.405
HELIX:
0.1258
FCONS_SCORE:
0
RIG_SCORE:
0.8232
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PMS2P5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRRKLRRLN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8MQ11
Postmeiotic segregation increased 2-like protein 5
DEG_APCC_DBOX_1
4:12
RRRKLRRLN
APC,CDC20,FZR1
0.8321
More...