DegronMD

Uniprot ID: Q15139

Source protein: Serine/threonine-protein kinase D1

Source gene: PRKD1

Class: DEG_APCC_DBOX_1

Location: 200:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5544

ASA_SCORE: 99.1111

COIL: 0.7656

CONS_SCORE: 0.4872

DSS_SCORE: 0.3032

HELIX: 0.1372

FCONS_SCORE: 0.8753

RIG_SCORE: 0.7819

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S197C	TCGA-50-6594	LUAD	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.25
p.S197C	DO24275	LUAD	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.25
p.R200M	TCGA-73-4659	LUAD	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.7521
p.R200M	DO24467	LUAD	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.7521
p.R216H	TCGA-A5-A0G2	UCEC	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216H	DO41235	UCEC	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216C	TCGA-AP-A0LM	UCEC	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216C	TCGA-G4-6295	COAD	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216C	DO9362	COAD	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216C	DO233055	GACA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R216C	DO43306	UCEC	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1111
p.R201W	TCGA-B5-A1MR	UCEC	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.8634
p.R201W	DO41758	UCEC	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.8634
p.V212I	TCGA-DF-A2KN	UCEC	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.2222
p.V212I	DO223282	UCEC	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.2222
p.F190C	TCGA-E6-A1LX	UCEC	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.0556
p.F190C	DO41020	UCEC	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.0556
p.V212A	TCGA-EI-6917	READ	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.2222
p.V212A	DO36881	READ	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.2222
p.F190L	TCGA-FK-A3SD	THCA	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.0556
p.F190L	DO39210	THCA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.0556
p.S213T	TCGA-HC-A6AL	PRAD	TCGA	RRRRLSNVS	DEG_APCC_DBOX_1	0.1944
p.S213T	DO46805	PRAD	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1944
p.N194T	DO222884	COCA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.1667
p.R203S	DO50434	ESAD	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.6316
p.G198S	DO233179	GACA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.2778
p.G198S	DO233748	GACA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.2778
p.V207F	DO232022	LICA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.7068
p.S205T	DO232002	LICA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.7116
p.G198C	DO35132	PACA	ICGC	RRRRLSNVS	DEG_APCC_DBOX_1	0.2778
p.R201Q	SIDM00214	Colorectal Carcinoma	GDSC	RRRRLSNVS	DEG_APCC_DBOX_1	0.7329
p.R201Q	ACH-000955	Colon/Colorectal Cancer	CCLE	RRRRLSNVS	DEG_APCC_DBOX_1	0.7329
p.R201Q	SNU-407	large_intestine	COSMIC	RRRRLSNVS	DEG_APCC_DBOX_1	0.7329

Drug responses associated with PRKD1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00983	BLCA\|bladder	p.D608H (No)	GDSC	kb NB 142-70	15.388
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	2.6918
SIDM00578	NB\|neuroblastoma	p.E493K (No)	GDSC	kb NB 142-70	2.4964
SIDM00190	SKCM\|melanoma	p.P585S (No)	GDSC	kb NB 142-70	11.8604
SIDM00678	BLCA\|bladder	p.P467T (No)	GDSC	kb NB 142-70	14.8617
SIDM00499	PRAD\|prostate	p.S332G (No)	GDSC	kb NB 142-70	19.8823
SIDM01032	ESCA\|oesophagus	p.N403S (No)	GDSC	kb NB 142-70	7.7758
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R105C (No)	GDSC	kb NB 142-70	2.705
SIDM00108	SKCM\|melanoma	p.G181S (No)	GDSC	kb NB 142-70	20.4081
SIDM00260	STAD\|stomach	p.Y760* (No)	GDSC	kb NB 142-70	23.6819
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.S136P (No)	GDSC	kb NB 142-70	4.9999
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Q143P (No)	GDSC	kb NB 142-70	6.2041
SIDM00989	BLCA\|bladder	p.G32_P33insSG (No)	GDSC	kb NB 142-70	9.0277
SIDM00348	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	47.5228
SIDM01107	SKCM\|melanoma	p.R408M (No)	GDSC	kb NB 142-70	31.2755
SIDM01007	ALL\|lymphoblastic_leukemia	p.V642A (No)	GDSC	kb NB 142-70	11.671
SIDM01007	ALL\|lymphoblastic_leukemia	p.L182P (No)	GDSC	kb NB 142-70	11.671
SIDM00537	COREAD\|large_intestine	p.M824fs*9 (No)	GDSC	kb NB 142-70	10.1133
SIDM00537	COREAD\|large_intestine	p.G32_P33insSG (No)	GDSC	kb NB 142-70	10.1133
SIDM00640	MESO\|mesothelioma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	10.5307
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	1.868
SIDM00847	UNCLASSIFIED\|rhabdomyosarcoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	16.2615
SIDM00145	ALL\|lymphoblastic_leukemia	p.G32_P33insSG (No)	GDSC	kb NB 142-70	4.9264
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	12.8373
SIDM00214	COREAD\|large_intestine	p.R201Q (Yes)	GDSC	kb NB 142-70	15.9794
SIDM00551	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	15.0621
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.S350I (No)	GDSC	kb NB 142-70	7.5758
SIDM01090	COREAD\|large_intestine	p.C853R (No)	GDSC	kb NB 142-70	6.0065
SIDM01090	COREAD\|large_intestine	p.G779D (No)	GDSC	kb NB 142-70	6.0065
SIDM00551	ESCA\|oesophagus	p.D615Y (No)	GDSC	kb NB 142-70	15.0621
SIDM01026	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	21.8818
SIDM00616	LIHC\|liver	p.G32_P33insSG (No)	GDSC	kb NB 142-70	16.2065
SIDM00185	SKCM\|melanoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	11.6731
SIDM00157	NB\|neuroblastoma	p.P314L (No)	GDSC	kb NB 142-70	2.2754
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	61.3956
SIDM00217	COREAD\|large_intestine	p.Q876H (No)	GDSC	kb NB 142-70	17.042
SIDM00217	COREAD\|large_intestine	p.R858C (No)	GDSC	kb NB 142-70	17.042
SIDM00217	COREAD\|large_intestine	p.P801S (No)	GDSC	kb NB 142-70	17.042
SIDM00807	BLCA\|bladder	p.A481T (No)	GDSC	kb NB 142-70	12.421
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K826E (No)	GDSC	kb NB 142-70	16.0814
SIDM00369	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	35.6863
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.G32_P33insSG (No)	GDSC	kb NB 142-70	47.8518
SIDM00216	COREAD\|large_intestine	p.E811K (No)	GDSC	kb NB 142-70	2.5083
SIDM00282	COREAD\|large_intestine	p.W532* (No)	GDSC	kb NB 142-70	62.3736
SIDM00282	COREAD\|large_intestine	p.A137T (No)	GDSC	kb NB 142-70	62.3736
SIDM01088	UNCLASSIFIED\|endometrium	p.G32_P33insSG (No)	GDSC	kb NB 142-70	2.7567
SIDM00660	COREAD\|large_intestine	p.R439Q (No)	GDSC	kb NB 142-70	15.8557
SIDM00542	GBM\|glioma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	14.4083
SIDM00886	DLBC\|B_cell_lymphoma	p.K268* (No)	GDSC	kb NB 142-70	3.1314
SIDM00783	COREAD\|large_intestine	p.S625N (No)	GDSC	kb NB 142-70	6.7015
SIDM00688	DLBC\|B_cell_lymphoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	3.3626
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V703L (No)	GDSC	kb NB 142-70	13.7108
SIDM00950	PAAD\|pancreas	p.H389N (No)	GDSC	kb NB 142-70	178.0448
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.E870Q (No)	GDSC	kb NB 142-70	3.837
SIDM00987	THCA\|thyroid	p.M166V (No)	GDSC	kb NB 142-70	15.8399
SIDM00627	CESC\|cervix	p.D384E (No)	GDSC	kb NB 142-70	3.8854
SIDM01026	ESCA\|oesophagus	p.G599E (No)	GDSC	kb NB 142-70	21.8818
SIDM00534	COREAD\|large_intestine	p.I571S (No)	GDSC	kb NB 142-70	31.7567
SIDM00350	HNSC\|head_and_neck	p.G32_P33insSG (No)	GDSC	kb NB 142-70	12.3526
SIDM00282	COREAD\|large_intestine	p.D71fs*47 (No)	GDSC	kb NB 142-70	62.3736
SIDM00241	BRCA\|breast	p.G32_P33insSG (No)	GDSC	kb NB 142-70	4.4386
SIDM00545	SKCM\|melanoma	p.G906D (No)	GDSC	kb NB 142-70	53.2414
SIDM00545	SKCM\|melanoma	p.G906S (No)	GDSC	kb NB 142-70	53.2414
SIDM00545	SKCM\|melanoma	p.G600E (No)	GDSC	kb NB 142-70	53.2414
SIDM00048	LUAD\|lung_NSCLC_adenocarcinoma	p.R603L (No)	GDSC	kb NB 142-70	32.6647
SIDM01136	PAAD\|pancreas	p.M902I (No)	GDSC	kb NB 142-70	16.0834
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S768Y (No)	GDSC	kb NB 142-70	20.8493
SIDM00672	LIHC\|liver	p.I808V (No)	GDSC	kb NB 142-70	6.6505
SIDM01059	SKCM\|melanoma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	6.4379
SIDM00283	DLBC\|B_cell_lymphoma	p.W444C (No)	GDSC	kb NB 142-70	5.0586
SIDM00250	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	8.896
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.V703I (No)	GDSC	kb NB 142-70	7.8961
SIDM00080	SKCM\|melanoma	p.R740W (No)	GDSC	kb NB 142-70	12.1828
SIDM00444	ESCA\|oesophagus	p.R618* (No)	GDSC	kb NB 142-70	11.0575
SIDM00383	UNCLASSIFIED\|stomach	p.K903E (No)	GDSC	kb NB 142-70	8.1404
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L697I (No)	GDSC	kb NB 142-70	10.8339
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.I326F (No)	GDSC	kb NB 142-70	47.8518
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.E811* (No)	GDSC	kb NB 142-70	4.8933
SIDM00303	OV\|ovary	p.G32_P33insSG (No)	GDSC	kb NB 142-70	15.3224
SIDM00944	COREAD\|large_intestine	p.H442R (No)	GDSC	kb NB 142-70	48.6698
SIDM00878	BRCA\|breast	p.A487V (No)	GDSC	kb NB 142-70	11.2264
SIDM01032	ESCA\|oesophagus	p.G32_P33insSG (No)	GDSC	kb NB 142-70	7.7758
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.G32_P33insSG (No)	GDSC	kb NB 142-70	3.1118
SIDM00571	UNCLASSIFIED\|pancreas	p.Q876* (No)	GDSC	kb NB 142-70	45.5497
SIDM00193	COREAD\|large_intestine	p.R603C (No)	GDSC	kb NB 142-70	79.4039
SIDM00118	COREAD\|large_intestine	p.P721S (No)	GDSC	kb NB 142-70	75.2333
SIDM00900	MM\|myeloma	p.G32_P33insSG (No)	GDSC	kb NB 142-70	22.944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRRLSNVS

Degron related mutations and impact score

Drug responses associated with PRKD1 mutations

All proteins holding degron of RRRRLSNVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15139	Serine/threonine-protein kinase D1	DEG_APCC_DBOX_1	200:208	RRRRLSNVS	APC,CDC20,FZR1	0.5544	More...