DegronMD

Uniprot ID: O75417

Source protein: DNA polymerase theta

Source gene: POLQ

Class: DEG_APCC_DBOX_1

Location: 2446:2454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8413

ASA_SCORE: 72.3889

COIL: 0.6456

CONS_SCORE: 0.4366

DSS_SCORE: 0.3649

HELIX: 0.0521

FCONS_SCORE: 1.1836

RIG_SCORE: 0.7963

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2460L	TCGA-68-8251	LUSC	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.R2460L	DO26858	LUSC	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.G2452E	TCGA-AA-3510	COAD	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.6087
p.G2452E	DO7783	COAD	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.6087
p.G2445V	TCGA-B6-A0RU	BRCA	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.3056
p.G2445V	DO1954	BRCA	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.3056
p.P2451S	TCGA-CG-5723	STAD	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.5641
p.P2451S	DO38376	STAD	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.5641
p.Q2441E	TCGA-CV-7099	HNSC	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.1944
p.Q2441E	DO15294	HNSC	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.1944
p.R2436I	TCGA-EM-A2CN	THCA	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.0556
p.R2436I	DO39886	THCA	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.0556
p.R2447H	TCGA-HT-8013	LGG	TCGA	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.R2447H	DO50412	ESAD	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.R2447H	DO22181	LGG	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.R2447H	SIDM00777	Colorectal Carcinoma	GDSC	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.R2447H	ACH-000360	Colon/Colorectal Cancer	CCLE	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.R2447H	NCI-H508	large_intestine	COSMIC	RRRYLPGIK	DEG_APCC_DBOX_1	0.8244
p.P2451Q	DO52603	BOCA	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.5924
p.I2453M	DO1073	BRCA	ICGC	RRRYLPGIK	DEG_APCC_DBOX_1	0.6507
p.H2463R	SIDM00122	Breast Carcinoma	GDSC	RRRYLPGIK	DEG_APCC_DBOX_1	0.0833
p.H2463R	BT-549	breast	COSMIC	RRRYLPGIK	DEG_APCC_DBOX_1	0.0833
p.R2460H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.R2460H	ACH-000937	Leukemia	CCLE	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.R2460H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.V2440I	SIDM01570	Ovarian Carcinoma	GDSC	RRRYLPGIK	DEG_APCC_DBOX_1	0.1667
p.G2438R	ACH-001164	Sarcoma	CCLE	RRRYLPGIK	DEG_APCC_DBOX_1	0.1111
p.F2453S	LS-180	large_intestine	COSMIC	RRRYLPGIK	DEG_APCC_DBOX_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRYLPGIK

Degron related mutations and impact score

Drug responses associated with POLQ mutations

All proteins holding degron of RRRYLPGIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75417	DNA polymerase theta	DEG_APCC_DBOX_1	2446:2454	RRRYLPGIK	APC,CDC20,FZR1	0.8413	More...