DegronMD

Uniprot ID: P26927

Source protein: Hepatocyte growth factor-like protein

Source gene: MST1

Class: DEG_APCC_DBOX_1

Location: 478:486

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7705

ASA_SCORE: 78.5111

COIL: 0.6472

CONS_SCORE: 0.5763

DSS_SCORE: 0.5577

HELIX: 0.0654

FCONS_SCORE: 0.9831

RIG_SCORE: 0.7239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R485M	TCGA-78-7633	LUAD	TCGA	RRSKLRVVG	DEG_APCC_DBOX_1	0.8632
p.R485M	DO24359	LUAD	ICGC	RRSKLRVVG	DEG_APCC_DBOX_1	0.8632
p.D472E	TCGA-BG-A3PP	UCEC	TCGA	RRSKLRVVG	DEG_APCC_DBOX_1	0.1667
p.D472E	DO48186	UCEC	ICGC	RRSKLRVVG	DEG_APCC_DBOX_1	0.1667
p.R493C	TCGA-DD-A1EC	LIHC	TCGA	RRSKLRVVG	DEG_APCC_DBOX_1	0.1389
p.R493C	DO22982	LIHC	ICGC	RRSKLRVVG	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26927	Hepatocyte growth factor-like protein	DEG_APCC_DBOX_1	478:486	RRSKLRVVG	APC,CDC20,FZR1	0.7705	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons