DegronMD

Uniprot ID: Q969G5

Source protein: Caveolae-associated protein 3

Source gene: CAVIN3

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9047

ASA_SCORE: 97

COIL: 0.239

CONS_SCORE: 0.9579

DSS_SCORE: 0.6198

HELIX: 0.7553

FCONS_SCORE: 1.0973

RIG_SCORE: 0.7157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A192G	SIDM00710	Small Cell Lung Carcinoma	GDSC	RRTGLQKVQ	DEG_APCC_DBOX_1	0.1944
p.A192G	NCI-H2081	lung	COSMIC	RRTGLQKVQ	DEG_APCC_DBOX_1	0.1944
p.R196Q	SIDM01608	Endometrial Carcinoma	GDSC	RRTGLQKVQ	DEG_APCC_DBOX_1	0.0833
p.S194L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	RRTGLQKVQ	DEG_APCC_DBOX_1	0.1389
p.A180T	NCI-H835	lung	COSMIC	RRTGLQKVQ	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969G5	Caveolae-associated protein 3	DEG_APCC_DBOX_1	179:187	RRTGLQKVQ	APC,CDC20,FZR1	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons