DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRTLFRE
Uniprot ID:
O60303
Source protein:
Katanin-interacting protein
Source gene:
KATNIP
Class:
LIG_APCC_ABBAyCdc20_2
Location:
107:113
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9889
ASA_SCORE:
104.3429
COIL:
0.4106
CONS_SCORE:
0.3277
DSS_SCORE:
0.525
HELIX:
0.5621
FCONS_SCORE:
1.0179
RIG_SCORE:
0.7745
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D104N
SIDM01154
T-Lymphoblastic Leukemia
GDSC
RRTLFRE
LIG_APCC_ABBAyCdc20_2
0.25
p.D104N
SIDM01608
Endometrial Carcinoma
GDSC
RRTLFRE
LIG_APCC_ABBAyCdc20_2
0.25
Drug responses associated with KATNIP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRTLFRE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60303
Katanin-interacting protein
LIG_APCC_ABBAyCdc20_2
107:113
RRTLFRE
APC,CDC20,FZR1
0.9889
More...