DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: LIG_APCC_ABBAyCdc20_2

Location: 280:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6356

ASA_SCORE: 43.9714

COIL: 0.1499

CONS_SCORE: 0.782

DSS_SCORE: 0.4078

HELIX: 0.8359

FCONS_SCORE: 1.2173

RIG_SCORE: 0.7701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R276C	TCGA-38-4631	LUAD	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R276C	DO24970	LUAD	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G271R	TCGA-AP-A059	UCEC	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G271R	TCGA-BG-A0M4	UCEC	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G271R	DO41686	UCEC	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G271R	DO41361	UCEC	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R276L	TCGA-CR-7388	HNSC	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R276L	DO14284	HNSC	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R290Q	TCGA-D3-A8GM	SKCM	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R290Q	DO50288	SKCM	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R276G	TCGA-ZF-A9R9	BLCA	TCGA	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R276G	DO219066	BLCA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V272L	DO228952	LICA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V272L	DO229031	LICA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.W296C	DO229031	LICA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.M283I	DO229031	LICA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.6507
p.G275C	DO229009	LICA	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V278L	DO231832	LINC	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T292A	DO36556	READ	ICGC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S295L	SIDM00381	Cervical Carcinoma	GDSC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S295L	ACH-002020	Cervical Cancer	CCLE	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S295L	SKG-IIIa	cervix	COSMIC	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G271A	ACH-001094	Myeloma	CCLE	RSLMYSE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	LIG_APCC_ABBAyCdc20_2	280:286	RSLMYSE	APC,CDC20,FZR1	0.6356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons