DegronMD

Uniprot ID: Q8N668

Source protein: COMM domain-containing protein 1

Source gene: COMMD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 36:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9752

ASA_SCORE: 81.5286

COIL: 0.7061

CONS_SCORE: 0.5981

DSS_SCORE: 0.3637

HELIX: 0.2563

FCONS_SCORE: 1.1453

RIG_SCORE: 0.7879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P41Q	TCGA-DO-A1JZ	THCA	TCGA	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.5924
p.P41Q	DO40472	THCA	ICGC	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.5924
p.P41S	TCGA-EE-A181	SKCM	TCGA	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P41S	DO37444	SKCM	ICGC	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P28H	TCGA-EE-A2M7	SKCM	TCGA	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P28H	DO37847	SKCM	ICGC	RSQLYPE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N668	COMM domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	36:42	RSQLYPE	APC,CDC20,FZR1	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons