DegronMD

Uniprot ID: Q16671

Source protein: Anti-Muellerian hormone type-2 receptor

Source gene: AMHR2

Class: LIG_APCC_ABBAyCdc20_2

Location: 22:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.655

ASA_SCORE: 54.9429

COIL: 0.3239

CONS_SCORE: 0.3587

DSS_SCORE: 0.3312

HELIX: 0.1057

FCONS_SCORE: 0.9582

RIG_SCORE: 0.871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R22Q	TCGA-B5-A11N	UCEC	TCGA	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	TCGA-GF-A4EO	SKCM	TCGA	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	DO9876	COAD	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	DO47559	SKCM	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	DO41458	UCEC	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	SIDM01240	Melanoma	GDSC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	ACH-001002	Skin Cancer	CCLE	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R22Q	451Lu	skin	COSMIC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.P12S	TCGA-D3-A3C1	SKCM	TCGA	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P12S	DO47323	SKCM	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P30L	TCGA-EE-A3J7	SKCM	TCGA	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P30L	DO48770	SKCM	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T13I	TCGA-FI-A2F4	UCEC	TCGA	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T13I	DO43434	UCEC	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V25M	DO228083	EOPC	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.6097
p.R33L	DO229259	THCA	ICGC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R33L	ACH-001377	Pancreatic Cancer	CCLE	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P19A	SIDM00970	Bladder Carcinoma	GDSC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.25
p.P19A	DSH1	urinary_tract	COSMIC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.25
p.R33W	DU-145	prostate	COSMIC	RTCVFFE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16671	Anti-Muellerian hormone type-2 receptor	LIG_APCC_ABBAyCdc20_2	22:28	RTCVFFE	APC,CDC20,FZR1	0.655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons