DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: LIG_APCC_ABBAyCdc20_2

Location: 1594:1600

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7244

ASA_SCORE: 97.7

COIL: 0.4523

CONS_SCORE: 0.3637

DSS_SCORE: 0.4529

HELIX: 0.5161

FCONS_SCORE: 1.0403

RIG_SCORE: 0.8137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1591K	TCGA-DX-A6YV	SARC	TCGA	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1594H	DO9114	COAD	ICGC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.A1589S	DO228985	LICA	ICGC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G1593C	DO229026	LICA	ICGC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R1595L	DO229031	LICA	ICGC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R1595Q	DO42568	UCEC	ICGC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.7329
p.I1586T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1586T	ACH-000981	Leukemia	CCLE	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1586T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	RTLLYQE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	LIG_APCC_ABBAyCdc20_2	1594:1600	RTLLYQE	APC,CDC20,FZR1	0.7244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons