DegronMD

Uniprot ID: Q13207

Source protein: T-box transcription factor TBX2

Source gene: TBX2

Class: LIG_APCC_ABBAyCdc20_2

Location: 251:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5093

ASA_SCORE: 54.7571

COIL: 0.4204

CONS_SCORE: 0.8527

DSS_SCORE: 0.0425

HELIX: 0.0111

FCONS_SCORE: 1.0101

RIG_SCORE: 0.9085

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R251C	DO35442	PACA	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R251H	DO52482	COCA	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.8244
p.T252A	TCGA-AY-6197	COAD	TCGA	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.7139
p.T252A	DO9956	COAD	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.7139
p.T252S	SIDM01954	Colorectal Carcinoma	GDSC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.7116
p.V254L	DO228948	LICA	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V254L	SIDM00588	Oral Cavity Carcinoma	GDSC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V254L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V254L	TE-4	oesophagus	COSMIC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V254L	HSC-4	upper_aerodigestive_tract	COSMIC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.5654
p.A262V	TCGA-EY-A5W2	UCEC	TCGA	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A262V	DO48177	UCEC	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D241G	TCGA-GC-A3RB	BLCA	TCGA	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D241G	DO530	BLCA	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q267H	TCGA-S5-A6DX	BLCA	TCGA	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q267H	DO51903	BLCA	ICGC	RTYVFPE	LIG_APCC_ABBAyCdc20_2	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13207	T-box transcription factor TBX2	LIG_APCC_ABBAyCdc20_2	251:257	RTYVFPE	APC,CDC20,FZR1	0.5093	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons