DegronMD

Uniprot ID: O15553

Source protein: Pyrin

Source gene: MEFV

Class: LIG_APCC_ABBAyCdc20_2

Location: 717:723

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5956

ASA_SCORE: 17.9714

COIL: 0.0386

CONS_SCORE: 0.5801

DSS_SCORE: 0.0843

HELIX: 0.0017

FCONS_SCORE: 1.3301

RIG_SCORE: 0.8874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G719V	TCGA-A8-A07U	BRCA	TCGA	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.6421
p.G727A	TCGA-DK-A1AC	BLCA	TCGA	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S730F	TCGA-FW-A3R5	SKCM	TCGA	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D723N	TCGA-GF-A3OT	SKCM	TCGA	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.6932
p.R708C	SIDM00461	Acute Myeloid Leukemia	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R708C	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R717C	SIDM00945	Colorectal Carcinoma	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R717C	CL-34	large_intestine	COSMIC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.8301
p.V726A	SIDM01120	Other Solid Cancers	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.V726A	SIDM00941	Kidney Carcinoma	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.V726A	SIDM00140	Melanoma	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.F721Y	SIDM00893	Breast Carcinoma	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.6417
p.F721Y	BT-20	breast	COSMIC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.6417
p.R717P	SIDM00927	Small Cell Lung Carcinoma	GDSC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.7512
p.R717P	NCI-H510A	lung	COSMIC	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.7512
p.D723E	ACH-000681	Lung Cancer	CCLE	RVGIFVD	LIG_APCC_ABBAyCdc20_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15553	Pyrin	LIG_APCC_ABBAyCdc20_2	717:723	RVGIFVD	APC,CDC20,FZR1	0.5956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons