DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RVPVFDD
Uniprot ID:
Q4G0W2
Source protein:
Dual specificity phosphatase 28
Source gene:
DUSP28
Class:
LIG_APCC_ABBAyCdc20_2
Location:
67:73
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9574
ASA_SCORE:
47.7429
COIL:
0.4874
CONS_SCORE:
0.6294
DSS_SCORE:
0.327
HELIX:
0.0173
FCONS_SCORE:
1.3176
RIG_SCORE:
0.806
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R59S
DO228056
EOPC
ICGC
RVPVFDD
LIG_APCC_ABBAyCdc20_2
0.1111
p.D77E
ACH-000357
Lymphoma
CCLE
RVPVFDD
LIG_APCC_ABBAyCdc20_2
0.2222
Drug responses associated with DUSP28 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RVPVFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4G0W2
Dual specificity phosphatase 28
LIG_APCC_ABBAyCdc20_2
67:73
RVPVFDD
APC,CDC20,FZR1
0.9574
More...